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KMID : 0378120020290020083
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Chungnam Medical Journal
2002 Volume.29 No. 2 p.83 ~ p.89
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The Effect of Tibolone on Qaulity of Life in Postmenopausal Women
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Kang Kil-Chun
Oh Young-Gyn
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Abstract
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The effect of tibolone, a synthetic steroid with tissue-specific activity, on quality of life in healthy postmenopausal women was studied. A total of 55 women were randomised to 2.5 ㎎ tibolone or to a calcium drug daily for 12 months. Quality of life was assessed by the Blumel method. Information on the occurrence of climacteric complaints and incidences of side effects were also gathered. Compared to baseline values. the tibolone group significantly improved on four out of six domains. including emotional disorder, energy reduction. physical mobility, and social isolation. However. the domains of sleep disorder and pain did not improve. This effect was not a placebo effect in comparison with the control group. The occurrence of hot flushes and nightly sweats was significantly- lower in the tibolone group compared to the control group after 12 months of treatment. Throughout the study period only a few women in the study group and the control group were observed. This did not cause a significant problem. Tibolone can improve the guality of life in postmenopausal women. but the exact mechanism remain to be resolved.
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KEYWORD
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Tibolone, Menopause, Qaulity of life
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